منابع مشابه
c-kit+ Cardiac Stem Cells
One of the lingering controversies in the field of cardiac regenerative medicine has been around the origin of c-kit cardiac stem cells in the heart and their contribution toward cardiac homeostasis. A recent study reports that a subpopulation of c-kit cardiac progenitors emerges from the cardiac neural crest (CNC) with the capacity to give rise to cardiomyocytes. Contribution of CNC-derived c-...
متن کاملMesenchymal stem cells enhance the differentiation of c-kit+ cardiac stem cells.
C-kit+ cardiac stem cells (CSCs) were isolated from neonatal rat and tested for the expression of Nkx2.5 and GATA-4 genes which are important in cardiac development. C-kit+ CSCs were plated into the well below the insert of transwell inserts and bone marrow mesenchymal stem cells (BMMSCs) were plated into the inserts. The expression of cardiac Troponin T (cTnT), p27, CDK2, transforming growth f...
متن کاملAngiotensin II promotes differentiation of mouse c-kit-positive cardiac stem cells into pacemaker-like cells
Cardiac stem cells (CSCs) can differentiate into cardiac muscle‑like cells; however, it remains unknown whether CSCs may possess the ability to differentiate into pacemaker cells. The aim of the present study was to determine whether angiotensin II (Ang II) could promote the specialization of CSCs into pacemaker‑like cells. Mouse CSCs were treated with Ang II from day 3-5, after cell sorting. T...
متن کاملResident c-kit+ cells in the heart are not cardiac stem cells
Identifying a bona fide population of cardiac stem cells (CSCs) is a critical step for developing cell-based therapies for heart failure patients. Previously, cardiac c-kit(+) cells were reported to be CSCs with a potential to become myocardial, endothelial and smooth muscle cells in vitro and after cardiac injury. Here we provide further insights into the nature of cardiac c-kit(+) cells. By t...
متن کاملSafety of Intracoronary Infusion of 20 Million C-Kit Positive Human Cardiac Stem Cells in Pigs
BACKGROUND There is mounting interest in using c-kit positive human cardiac stem cells (c-kit(pos) hCSCs) to repair infarcted myocardium in patients with ischemic cardiomyopathy. A recent phase I clinical trial (SCIPIO) has shown that intracoronary infusion of 1 million hCSCs is safe. Higher doses of CSCs may provide superior reparative ability; however, it is unknown if doses >1 million cells ...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2016
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.115.308103